Joe Rogan Experience #736 - Brendan Schaub & Bryan Callen

Episode Summary

Main Topics Discussed

• Propecia Side Effects: Joe Rogan and guests discuss severe side effects of Propecia, including decreased endurance, strength, sex drive, and instances of severe depression (e.g., Ari Shafir).
• Anti-Aging & Medical Regeneration: Conversation around cutting-edge procedures like Regenicine (Peter Welling, endorsed by Kobe Bryant) for collagen regeneration and anti-aging, potential for regenerating spinal tissue, and successful penis transplants.
• Future of Medicine: Discussion on CRISPR gene editing as the "new frontier," concerns about overpopulation due to extended lifespans, and the high cost of advanced medical treatments (e.g., Hep C cure).
• Aging and Attraction: Personal anecdotes about aging in the entertainment industry, declining female attention, and the extraordinary efforts celebrities like Christie Brinkley and Cindy Crawford undertake to maintain youthfulness.
• UFC Matchmaking and Rankings: A deep dive into controversial UFC decisions regarding immediate title rematches (Aldo vs. McGregor, Rousey vs. Holm, Barao, Anderson Silva), the inconsistency in fighter rankings, and the inherent conflict of interest with the UFC acting as both sanctioning body and promoter.
• Proposed UFC Contender Selection System: Suggestion for a public, media, and fighter voting system to determine title contenders, similar to the Golden Globes.
• Fight Breakdowns & Predictions: Analysis of recent fights (Frankie Edgar vs. Chad Mendes, Yoel Romero vs. Jacare Souza) and future dream matchups (Cowboy Cerrone vs. Dos Anjos winner vs. Conor McGregor).

Key Insights & Memorable Moments

• Joe Rogan's emphatic warning about Propecia: "Propecia is bad for your dick, for your wang, for your dick."
• The revelation about Regenicine's potential to regenerate collagen and eliminate wrinkles, with Joe exclaiming, "You are going to look like a much younger person. And this is all within like the next year."
• The profound discussion on the mental devastation of groin injuries for young men, particularly veterans, highlighting how it can be more impactful than losing limbs.
• Brendan Schaub's confident, though possibly exaggerated, claim of calling every single fight correctly, including main events.
• The "pose off" between the 48-year-old comedians, illustrating their ongoing, playful competitiveness and refusal to "grow up."
• Demian Maia's honorable philosophy, as recounted by Joe: "I just do punching to set up my takedown so I can do jiu-jitsu because I don't want to hurt my opponent. I want to be able to train the next day."
• The concern that while medical advancements can fix most body parts, the brain remains the biggest frontier they "can't figure out."
• Bryan Callen's intriguing theory about Conor McGregor's striking: "I think Conor McGregor is has a secret, which is he's he's watching these guys strike and knows something they don't know."

Notable Quotes or Revelations

• "When I got off of it [Propecia], my endurance like upped really. Yeah. My strength like I felt stronger, like I felt like physically better like I would get tired like when I was on that. Yeah. I heard there's terrible side effects. Ari Shafir experienced severe depression from Propecia..." - Joe Rogan
• "Killed my dick like a bullet." - Brendan Schaub on Propecia's effect on sex drive.
• "This crisper this crisper cast 9 is fucking incredible. That that's the new frontier. And in 10 years we're going to be we're going to be literally taking your DNA and putting a gene in the area." - Joe Rogan
• "The thing is, you know, the one thing they can't figure out how to help your brain. It's the only thing they can't figure out. Everything else, you're good." - Joe Rogan
• "You can't play favorites cuz when the when the when the public smells favorites, then you're losing credibility." - Brendan Schaub on UFC matchmaking.
• "I said honestly I don't think that a rematch is the right... The problem with doing a rematch is it'd be so hard to sell when a guy gets knocked out that quick." - Joe Rogan on Aldo vs. McGregor II.

Overall Themes

• The Paradox of Progress: While celebrating incredible medical and scientific advancements, the podcast also explores their potential downsides, such as overpopulation and ethical dilemmas in combat sports.
• Defying Age: A recurring theme is the human desire to combat aging, both for physical appearance and athletic performance, highlighting both the natural process and the extremes people go to maintain youth.
• Integrity vs. Commercialism: A critical examination of the UFC's operational model, raising questions about whether financial incentives compromise the integrity and fairness of competition within mixed martial arts.
• Personal Passion and Professional Roles: Joe Rogan, despite his professional role as a UFC commentator, expresses his personal passion for the sport and his own "research" into fights, often independent of official guidelines.